Â鶹ֱ²¥

The Institute of Biomedical and Biosciences Research
The Clore Laboratory
University of Â鶹ֱ²¥
Hunter Street
Â鶹ֱ²¥
MK18 1EG, UK
Tel (office): Ìý+44 (0)1280 820370
Tel (lab): Ìý+44 (0)1280 820237

Biography

Mohamed was awarded his BSc Biochemistry and his MSc Nutrition and Human Physiology from the School of Sciences and his PhD from Medical School, (University of Burgundy, France) where he worked on the effect of metformin (oral anti-diabetic drug) on hepatic protein metabolism regulation.

Mohamed joined the Clore laboratory in 2005 to bring his extensive experience in metabolic diseases acquired at Dospharm Biotech Company and the European Centre of Bioprospectives (Normandy, France) where he was managing collaborative research with Lipha-Merck, Air Liquid Sante and ÌýBeaufour-IPSEN on the investigation of novel drugs for the treatment of degenerative diseases such as Alzheimer’s and diabetes.

Mohamed is Director of the Institute of Biomedical and Bioscience Research (IBBR). He is leading the University research group in Biomedical Research. The group is investigating the beneficial effects of pharmaceutical drugs and plant-based medicines on inflammation, oxidative stress, obesity, type 2 diabetes, and neurodegenerative diseases in partnership with our academic and industrial collaborators.

Main research interests

• Plant treatments for syndrome X (metabolic syndrome), obesity and diabetes
• Thermogenesis stimulation in muscle and adipose tissue
• Adipose tissue expansion and angiogenesis
• Oxidative stress, inflammation and degenerative diseases,
• Regulation of hepatic and adipose cells metabolism

Teaching Experience

• Visiting Lecturer in nutrition and metabolic diseases
  Faculties of Medicine & Pharmacy, University of Monastir, Tunisia
• Lecturer in biology applied to human health and nutrition
  College Superieur Saint Anselme, 27300 Bernay, Normandy, France
• Part-time lecturer in cell biology
  University of Rouen, France

Selected Publications (last 5 years)

Zaibi MS, Kępczyńska MA, Harikumar P, Alomar SY, Trayhurn P. IL-33 stimulates expression of the GPR84 (EX33) fatty acid receptor gene and of cytokine and chemokine genes in human adipocytes. Cytokine. 2018 Oct;110:189-193. doi: 10.1016/j.cyto.2018.05.008. Epub 2018 May 16.

Ben Khedher MR, Hammami M, Arch JRS, Hislop DC, Eze D, Wargent ET, KÄ™pczyÅ„ska MA, Zaibi MS. Preventive effects ofÌýSalvia officinalisÌýleaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone. PeerJ. 2018 Jan 9;6:e4166. doi: 10.7717/peerj.4166. eCollection 2018

Muredda L, Kępczyńska MA, Zaibi MS, Alomar SY, Trayhurn P. IL-1β and TNFα inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids. Arch Physiol Biochem. 2018 May;124(2):97-108. doi: 10.1080/13813455.2017.1364774. Epub 2017 Aug 24.

Kępczyńska MA, Zaibi MS, Alomar SY, Trayhurn P. PCR arrays indicate that the expression of extracellular matrix and cell adhesion genes in human adipocytes is regulated by IL-1β (interleukin-1β). Arch Physiol Biochem. 2017 Feb;123(1):61-67. doi: 10.1080/13813455.2016.1248979. Epub 2016 Nov 18.

Gentili A, Zaibi MS, Alomar SY, De Vuono S, Ricci MA, Alaeddin A, Siepi D, Boni M, Vaudo G, Trayhurn P, Lupattelli G. Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1β (MIP-1β), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery. Horm Metab Res. 2016 Dec; 48(12):847-853. Epub 2016 Jun 14.

Alomar SY, Gentili A, Zaibi MS, Kępczyńska MA, Trayhurn P. IL-1β (interleukin-1β) stimulates the production and release of multiple cytokines and chemokines by human preadipocytes. Arch Physiol Biochem. 2016 Jul;122(3):117-22. doi: 10.3109/13813455.2016.1156706.

Harzallah A, Hammami M, Kępczyńska MA, Hislop DC, Arch JR, Cawthorne MA, Zaibi MS. Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model. Arch Physiol Biochem. 2016;122(2):75-87. doi: 10.3109/13813455.2016.1148053.

Alomar SY, Zaibi MS, Kępczyńska MA, Gentili A, Alkhuriji A, Mansour L, Dar JA, Trayhurn P. PCR array and protein array studies demonstrate that IL-1β (interleukin-1β) stimulates the expression and secretion of multiple cytokines and chemokines in human adipocytes. Arch Physiol Biochem. 2015;121(5):187-93. doi: 10.3109/13813455.2015.1087034.

Wargent ET, Zaibi MS, O’Dowd JF, Cawthorne MA, Wang SJ, Arch JR, Stocker CJ. Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes. PeerJ. 2015 Feb 5;3:e753. doi: 10.7717/peerj.753. eCollection 2015.

Ngala RA, Zaibi MS, Langlands K, Stocker CJ, Arch JR, Cawthorne MA. Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy) psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3. PeerJ. 2014 Oct 7;2:e614. doi: 10.7717/peerj.614. eCollection 2014.

Wargent ET,ÌýZaibi MS, Silvestri C, Hislop DC, Stocker CJ, Stott CG, Guy GW, Duncan M, Di Marzo V, Cawthorne MA (2013). The cannabinoid delta-9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.ÌýÌýNutr DiabetesÌý3 e68Ìý

Christiansen E, Hansen SVF, Urban C, Hudson B, Wargent ET, Grundmann M, Jenkins L,ÌýZaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T (2013). Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes.ÌýACS Med Chem LettÌý4(5): 441-445ÌýÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD,ÌýZaibiÌý²Ñ, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T (2013). Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.ÌýJ Med ChemÌý56(3): 982-92ÌýÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý ÌýÌý

Wargent ET, O’Dowd JF,ÌýZaibiÌý²ÑS, Gao D, Bing C, Trayhurn P, Cawthorne MA, Arch JR, Stocker CJ (2013). Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice.ÌýÌýÌýJ EndocrinolÌý216(2): 157-68Ìý

Bellahcene M, O’Dowd JF, Wargent ET,ÌýZaibiÌý²ÑS, Hislop DC, Ngala RA, Smith DM, Cawthorne MA, Stocker CJ, Arch JR (2012). Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.ÌýÌýBr J NutrÌý109(10): 1755-64Ìý

Stocker CJ, Wargent ET, Martin-Gronert MS, Cripps RL, O’Dowd JF,ÌýZaibiÌýMS, Cottrell EC, Mercer JG, Duncan JS, Cawthorne MA, Ozanne SE, Arch JR (2012). Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y.ÌýInt J ObesÌý36(8): 1040-6ÌýÌý

Zaibi MS, Stocker CJ, O’Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJH, Smith DM, Arch JRS (2010). Roles of GPR41 and GPR43 in leptin secretory responses of murin adipocytes to short chain fatty acids.ÌýFEBS LettÌý384(11): 2381–2386Ìý

Bozaoglu K, Curran JE, Stocker CJ,ÌýZaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HHH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JBM (2010). Chemerin, a Novel Adipokine in the Regulation of Angiogenesis. ÌýJ Clin Endocrinol MetabÌý95(5): 2476-2485Ìý